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FABP1 in wonderland.

Alessandro Prinetti¹, Nico Mitro²

¹Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano, Italy.

Journal of Neurochemistry

|June 23, 2016

Summary

The liver serves as a crucial arachidonic acid reservoir, supplying the brain for endocannabinoid synthesis. Therapeutics targeting liver FABP1 should consider its role in brain fatty acid supply.

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Area of Science:

Neuroscience
Biochemistry
Endocrinology

Background:

Cannabinoid receptors are vital in the brain, regulating memory, cognition, movement, and pain.
Endogenous cannabinoids, like 2-arachidonoylglycerol (2-AG), are synthesized from circulating fatty acids.
The brain's source of fatty acids for endocannabinoid production has been a key research question.

Discussion:

This editorial highlights research demonstrating the liver's role as an arachidonic acid pool.
The liver's fatty acid pool can supply the brain for endocannabinoid synthesis under specific conditions.
Fatty acid-binding protein 1 (FABP1) in the liver is identified as a critical component in this process.

Key Insights:

The liver acts as a significant reservoir of arachidonic acid for the brain.
FABP1 plays a crucial role in regulating the availability of arachidonic acid for endocannabinoid production.
This finding has implications for understanding brain endocannabinoid system regulation.

Outlook:

Future therapeutics targeting liver FABP1 must consider its impact on the brain's endocannabinoid system.
Further research is needed to elucidate the precise mechanisms of liver-to-brain fatty acid transport for endocannabinoid synthesis.
Understanding this pathway could open new avenues for treating neurological and pain-related disorders.