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Updated: Mar 19, 2026
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis
Yanqiu Chen1, Lifeng Zhou1, Yan Yang2
1Guangzhou Medical College, Guangzhou Women and Children's Medical Center, Department of Otolaryngology, Guangzhou, China.
Introduction:
The role of platelet activation in allergic inflammation is receiving increasing attention. Sublingual immunotherapy for allergic rhinitis can modify the immunological process to an allergen, rather than simply treating symptoms.
Objective:
The aim of this study was to explore the role of platelet activation during sublingual immunotherapy in children with allergic rhinitis.
Methods:
Forty-two House Dust Mite - sensitized children with allergic rhinitis were enrolled and received House Dust Mite allergen extract for sublingual immunotherapy or placebo. Serum of different time points during treatment was collected and used for detection of Platelet Factor-4 and Beta-Thromboglobulin concentration by Enzyme-Linked Immuno Sorbent Assay.
Results:
Our data showed decreased expression of Platelet Factor-4 and Beta-Thromboglobulin protein after one year's sublingual immunotherapy. In addition, the decrease of symptom scores and serum Platelet Factor-4 and Beta-Thromboglobulin protein concentrations was positively related.
Conclusion:
During sublingual immunotherapy, platelet activation was inhibited significantly. Our results might indicate that inhibition of platelet activation within the systemic circulation is an important mechanism during sublingual immunotherapy.
