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Published on: December 3, 2019
Long-term Bone Mineral Density Changes in Antiretroviral-Treated HIV-Infected Individuals
Philip M Grant1, Douglas Kitch2, Grace A McComsey3
1Division of Infectious Diseases, Department of Medicine, Stanford University, Palo Alto.
Abstract:
We compared adjusted bone mineral density (BMD) changes between human immunodeficiency virus (HIV)-infected individuals during the first approximately 7.5 years after antiretroviral therapy (ART) initiation and HIV-uninfected controls. HIV-infected individuals (n = 97) had significantly greater adjusted BMD decline than controls (n = 614) during the first 96 weeks of ART. Subsequently, the rate of BMD decline slowed in HIV-infected individuals but remained greater than the rate of decline in HIV-uninfected individuals at the lumbar spine but not at the hip. In HIV-infected individuals after 96 weeks, no HIV- or treatment-related characteristic was associated with BMD loss, but lower lean body mass was associated with greater BMD loss at both lumbar spine and hip.
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