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Approach to biomarker testing: perspectives from various specialties.
M R Sung1, P M Ellis2, S Verma3
1Princess Margaret Cancer Centre, University Health Network, Toronto, ON;
Current Oncology (Toronto, Ont.)
|June 23, 2016
Summary
Biomarker testing for lung cancer is crucial for patient outcomes, but its integration in Canada is inconsistent. Physician perspectives reveal challenges like cost and funding, highlighting a need for standardized molecular testing protocols.
Area of Science:
- Oncology
- Molecular Diagnostics
- Health Services Research
Background:
- Biomarker testing is vital for lung cancer patient outcomes but not uniformly implemented in Canada.
- Understanding physician perspectives on current practices and challenges is essential for improving integration.
Purpose of the Study:
- To assess Canadian lung cancer specialists' perspectives on biomarker testing.
- To identify current practice patterns, challenges, and potential improvements for molecular testing in lung cancer.
Main Methods:
- A national survey of 375 Canadian lung cancer specialists was conducted.
- The 11-item survey focused on current practices and challenges of biomarker testing.
Main Results:
- A 36% response rate was achieved, with near-universal agreement on the impact of genotyping on patient outcomes and treatment decisions.
- Medical oncologists most often initiated testing, but a shared model with pathologists was preferred. Barriers included cost, funding, tissue, and sample quality.
- Over half of respondents perceived that <25% of test results inform first-line treatment decisions.
Conclusions:
- Consensus exists on the importance of biomarker testing for lung cancer treatment.
- A need for consensus on who should initiate molecular testing and clear clinical guidance for pathologists is evident.
- Facilitating testing requires improved diagnostic requisitions with essential patient information.
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