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Anxiety and Methylenetetrahydrofolate Reductase Mutation Treated With S-Adenosyl Methionine and Methylated B Vitamins
Shanna Anderson1, Jacob Panka1, Robin Rakobitsch1
1Shanna Anderson, ba ; Jacob Panka, ba ; Robin Rakobitsch, ba ; and Kaitlin Tyre, ba , are students at the National College of Natural Medicine (NCNM) in Portland, Oregon. Kerry Pulliam, MD, is a family medicine practitioner in private practice in Portland, Oregon.
Abstract:
This case report highlights challenges faced in the clinical management of patients with methylenetetrahydrofolate reductase (MTHFR) gene mutations and the importance of precise dosage when recommending methylated B vitamins to compensate for deficiencies caused by the polymorphism or symptoms related to the polymorphism. It also underscores the importance of obtaining ongoing objective assessments of anxiety (eg, Patient Reported Outcomes Measurement Information System, or PROMIS) to help gauge patient response.
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