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Updated: Aug 12, 2026
07:06
A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum
Published on: April 10, 2018
[Skin eruption and histopathological changes in dengue fever]
Gaoxiong Yi Xue Ke Xue Za Zhi = the Kaohsiung Journal of Medical Sciences
|January 1, 1989
Summary
Histopathological analysis of dengue fever skin lesions reveals endothelial cell swelling and neutrophil infiltration. These changes contribute to hemorrhage and tissue damage in dengue skin manifestations.
Area of Science:
- Dermatopathology
- Virology
- Immunology
Background:
- Dengue fever is a significant global health concern.
- Skin manifestations are common in dengue fever patients.
- Understanding the histopathology of dengue skin lesions is crucial.
Observation:
- Histopathological examination of skin eruptions in three dengue fever patients was conducted.
- Key findings included endothelial cell swelling in dermal vessels.
- Neutrophil diapedesis, erythrocyte extravasation, and mononuclear cell infiltration were observed.
Findings:
- Ultrastructural analysis showed degeneration of endothelial cells and neutrophils.
- The study identified a link between endothelial cell damage and inflammatory cell infiltration.
- Hemorrhage in skin lesions is associated with these pathological changes.
Implications:
- These findings enhance understanding of dengue pathogenesis.
- The research provides insights into the cellular mechanisms behind dengue skin symptoms.
- Further research can explore therapeutic targets for managing dengue-related skin issues.
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