Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

2.7K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.7K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.3K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.3K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

1.4K
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.4K
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

257
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
257
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

56
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
56
Guidelines for Nursing Documentation I01:30

Guidelines for Nursing Documentation I

2.5K
Quality documentation and reporting share essential characteristics that ensure they are practical and valuable resources for those who use them. These characteristics are:
Factual:  
The following points emphasize the significance of upholding accurate and unbiased documentation in healthcare.
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of Emergency Department Visits Among Midlife and Older Adults Screening Positive for Alcohol Misuse.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2026
Same author

A mixed methods assessment of an electronic health record-embedded intervention with supportive education and outreach to increase in-hospital opioid use disorder treatment initiation.

Journal of hospital medicine·2026
Same author

Reply: Comparative Dose-Response of Diazepam, Lorazepam, and Phenobarbital for Alcohol Withdrawal in the Emergency Department.

The Annals of pharmacotherapy·2025
Same author

Predictors of naltrexone prescribing for alcohol use disorder from the emergency department.

Alcohol, clinical & experimental research·2025
Same author

Comparative Dose Response of Diazepam, Lorazepam, and Phenobarbital for Alcohol Withdrawal in the Emergency Department.

The Annals of pharmacotherapy·2025
Same author

Integrating PRISM with User-centered Design (PRISM+UCD): Designing clinical decision support for safe opioid prescribing.

Research square·2025
Same journal

Climate Change and Emergency Medicine: A Scoping Review Across Emergency Medicine Subspecialties.

The western journal of emergency medicine·2026
Same journal

Clinician-documented Firearm Access and Safety Interventions for Veterans Receiving Suicide Risk Evaluation in VA Emergency Care Settings.

The western journal of emergency medicine·2026
Same journal

Clinical Insights and Case Analysis of Disorders Attributed to Cicadas in the Emergency Department.

The western journal of emergency medicine·2026
Same journal

Worth the Wait? Comparison of Emergency Department Patients' Waiting Room Tolerance for Real Patient Care vs Training/Simulation Scenarios.

The western journal of emergency medicine·2026
Same journal

Pilot Simulation Task Trainer for Prehospital Management of Neck Hemorrhage.

The western journal of emergency medicine·2026
Same journal

Changes in THC Positivity Rates in Adolescents Corresponding to Legalization of Recreational Marijuana in Illinois.

The western journal of emergency medicine·2026
See all related articles

Related Experiment Videos

Quality Improvement Initiative to Decrease Variability of Emergency Physician Opioid Analgesic Prescribing.

John H Burton1, Jason A Hoppe2, Jeff M Echternach1

  • 1Carilion Clinic, Department of Emergency Medicine, Roanoke, Virginia.

The Western Journal of Emergency Medicine
|June 23, 2016
PubMed
Summary
This summary is machine-generated.

A quality improvement initiative significantly reduced opioid prescribing variability in the emergency department (ED) by sharing peer data. This led to a 60% decrease in prescribing rates and fewer pills per prescription.

Related Experiment Videos

Area of Science:

  • Emergency Medicine
  • Health Services Research
  • Quality Improvement

Background:

  • Pain management is essential in emergency medicine, with variable opioid prescribing practices.
  • High variability in opioid prescribing suggests a need for improved consensus and care.
  • A quality improvement initiative was designed to standardize ED opioid analgesic prescribing.

Purpose of the Study:

  • To evaluate the impact of a three-part quality improvement initiative on emergency department (ED) opioid prescribing.
  • To reduce variability in opioid prescribing rates among physicians.
  • To assess changes in the quantity of pills prescribed per opioid prescription.

Main Methods:

  • A three-stage quality improvement initiative was implemented across seven ED sites.
  • Physicians received progressively detailed feedback on their opioid prescribing rates compared to peers.
  • Outcomes measured included prescribing rate variability, standard deviation, and mean quantity of pills per prescription.

Main Results:

  • Opioid prescribing rate variability decreased by 46% in Stage 2 and 60% in Stage 3 (p<0.01).
  • The mean quantity of pills per prescription reduced by 18% (p<0.01) across the initiative.
  • The overall group mean prescribing rate also significantly decreased through each stage.

Conclusions:

  • Systematic sharing of peer prescribing rates effectively reduces ED physician opioid prescribing variability.
  • Normative feedback is a valuable tool for standardizing opioid prescribing practices.
  • The initiative demonstrated a significant improvement in the quality of opioid prescribing in the ED.