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Apolipoprotein C3 gene variants and the risk of coronary heart disease: A meta-analysis

Yan Li1, Chao Li2, Jie Gao3

  • 1Department of Epidemiology, Beijing An zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

Meta Gene
|June 23, 2016
PubMed

Insights

This meta-analysis found that two apolipoprotein C3 gene single nucleotide polymorphisms (SNPs), SstI and T-455C, are associated with increased coronary heart disease (CHD) risk. Further studies are needed to confirm these findings on CHD risk factors.

Area of Science:

  • Genetics and Cardiovascular Disease Research
  • Molecular Epidemiology
  • Biomarker Discovery

Background:

  • Apolipoprotein C3 (APOC3) gene polymorphisms (SstI, C-482T, T-455C) have been implicated in coronary heart disease (CHD) risk.
  • Previous studies show inconsistent results and potential ethnicity variations regarding these associations.

Purpose of the Study:

  • To conduct a systematic meta-analysis evaluating the association between three APOC3 gene single nucleotide polymorphisms (SNPs) and the risk of CHD.
  • To consolidate existing evidence and clarify the relationship between these genetic variations and cardiovascular risk.

Main Methods:

  • Systematic literature search of HuGE Navigator and PubMed databases up to September 25, 2015.
  • Data extraction and quality assessment by two independent reviewers.
  • Random-effect model employed for meta-analysis to pool effect sizes.

Main Results:

  • Included 29 studies with a total of 11,186 subjects for SstI, 3,727 for C-482T, and 6,753 for T-455C.
  • Significant increase in CHD risk observed for SstI polymorphism (S2 vs. S1: OR=1.30, 95% CI 1.10-1.55).
  • Significant increasing trend of CHD risk found for T-455C polymorphism (C vs. T: OR=1.28, 95% CI 1.16-1.41).
  • No significant association found between C-482T polymorphism and CHD risk.

Conclusions:

  • Pooled evidence suggests SstI and T-455C SNPs in the APOC3 gene are associated with increased CHD risk.
  • The C-482T SNP did not show a significant association with CHD risk in this meta-analysis.
  • Further large-scale, well-designed studies are recommended to validate these findings due to limited sample size and heterogeneity.
Abstract

Keywords:
Apolipoprotein C3Coronary heart diseaseMeta-analysis

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