Cytoplasmic vacuolization in cell death and survival
Andrey V Shubin1,2,3, Ilya V Demidyuk1, Alexey A Komissarov1
1Laboratory of Protein Engineering, Institute of Molecular Genetics, Moscow, Russia.
Oncotarget
|June 23, 2016
Summary
Cytoplasmic vacuolization, a cell response to pathogens and compounds, is reviewed. New molecular data clarify its role in cell death and survival processes.
Area of Science:
- Cell Biology
- Pathology
- Molecular Biology
Background:
- Cytoplasmic vacuolization is a common cellular response observed in mammalian cells.
- This phenomenon is triggered by various factors, including pathogen exposure and chemical compounds.
- The precise role of vacuolization in cell death pathways has remained largely unclear due to a historical focus on morphology.
Purpose of the Study:
- To review recent advancements in understanding cytoplasmic vacuolization.
- To explore the molecular mechanisms underlying vacuole formation and structure.
- To elucidate the role of cytoplasmic vacuolization in cell death and survival.
Main Methods:
- Literature review of recent scientific data.
- Analysis of morphological and molecular studies on vacuolization.
- Synthesis of information on cell death types associated with vacuolization.
Main Results:
- Emerging data reveal molecular mechanisms of vacuole formation and structure.
- Numerous associations between vacuolization and novel cell death types have been identified.
- The study highlights a shift from purely morphological observations to molecular insights.
Conclusions:
- Cytoplasmic vacuolization is a complex process with implications for cell fate.
- Understanding its molecular basis is crucial for deciphering its role in cell death and survival.
- Further research integrating molecular and cellular data is warranted.
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