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Colitis as the Sole Initial Presentation of Chronic Granulomatous Disease: Histopathologic Clues to Diagnosis
Brooke E Rosenbaum1, Rivfka Shenoy, Sharon Vuppula
1From the *New York University School of Medicine, New York, New York; †Division of Pediatric Infectious Diseases, Department of Pediatrics, ‡Department of Pathology, and §Division of Pediatric Gastroenterology, Department of Pediatrics, New York University School of Medicine, New York, New York.
Abstract:
Chronic granulomatous disease is a rare, inherited immunodeficiency disorder that reduces the superoxide generation ability of phagocytes, leading to recurrent infections and granulomatous inflammation. We report the case of a previously healthy 3-year-old boy who presented with classic features of Crohn disease. Suspicion from histopathologiclogic assessment allowed early diagnosis and treatment for chronic granulomatous disease before the onset of infections.
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