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Published on: January 26, 2024
Positive and negative functions of B lymphocytes in tumors
Meng Shen1,2,3, Qian Sun1,2,3, Jian Wang1,2,3
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Abstract:
Accumulating evidence indicated that B lymphocytes exerted complex functions in tumor immunity. On the one hand, B lymphocytes can inhibit tumor development through antibody generation, antigen presentation, tumor tissue interaction, and direct killing. On the other hand, B lymphocytes have tumor-promoting functions. A typical type of B lymphocytes, termed regulatory B cells, is confirmed to attenuate immune response in a tumor environment. In this paper, we summarize the current understanding of B-cell functions in tumor immunology, which may shed light on potential therapeutic strategies against cancer.
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