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Updated: Mar 19, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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[SIRT1].

Yorito Hattori, Masafumi Ihara

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |June 24, 2016
    PubMed
    Summary

    Silent information regulator 1 (SIRT1) protein may combat cardiovascular and neurodegenerative diseases. SIRT1 activation shows potential for treating vascular cognitive impairment and cerebral infarction by reducing inflammation and apoptosis.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Neuroscience

    Context:

    • Silent information regulator 1 (SIRT1) is a protein deacetylase linked to the 'longevity gene'.
    • SIRT1 plays a role in suppressing cardiovascular and neurodegenerative diseases in model organisms.
    • Cerebral hypoperfusion/ischemia, inflammation, and apoptosis are implicated in vascular cognitive impairment.

    Purpose:

    • To explore the therapeutic potential of SIRT1 in cardiovascular and neurodegenerative diseases.
    • To investigate SIRT1's role in countering cerebral hypoperfusion and ischemia.
    • To identify SIRT1 as a molecular target for vascular cognitive impairment and cerebral infarction.

    Summary:

    • SIRT1, a protein deacetylase, exhibits protective effects against myocardial infarction and neurodegenerative conditions like Alzheimer's, ALS, and Parkinson's.

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  • It functions through anti-apoptotic, anti-inflammatory mechanisms, and by enhancing mitochondrial biogenesis.
  • SIRT1 also mitigates cerebral hypoperfusion/ischemia by deacetylating key molecules and promoting arterial dilation.

    • Impact:

    • SIRT1 potentiation offers promising therapeutic targets for vascular cognitive impairment.
    • SIRT1 activation may provide novel interventions for cerebral infarction.
    • Understanding SIRT1's mechanisms can advance treatments for age-related and vascular-related cognitive decline.