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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Intravenous thrombolysis and three-year ischemic stroke mortality
K Chwojnicki1, G Kozera1,2, P Sobolewski3
1Department of Neurology, Medical University of Gdańsk, Gdańsk, Poland.
Acta Neurologica Scandinavica
|June 24, 2016
Summary
Intravenous thrombolysis (IVT) for ischemic stroke (IS) improves three-year survival. Key predictors of long-term mortality include older age and stroke severity, not IVT itself.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Public Health
Background:
- Intravenous thrombolysis (IVT) is a critical treatment for ischemic stroke (IS).
- While IVT's effect on short-term mortality is known, its impact on long-term survival remains less clear.
- Understanding long-term outcomes is crucial for optimizing stroke care.
Purpose of the Study:
- To compare three-year mortality rates in IS patients treated with IVT versus those not treated.
- To identify predictors of long-term mortality after IVT for IS.
Main Methods:
- A cohort of 366 IS patients was analyzed from the Pomeranian Stroke Register.
- 196 patients received IVT, while 170 matched controls did not.
- Three-year survival and its determinants were estimated using statistical models.
Main Results:
- IVT was not significantly associated with three-month mortality in univariate analysis.
- Independent predictors of unfavorable long-term outcome included older age, parenchymal hemorrhage type 2, and higher modified Rankin Scale scores at discharge.
- IVT demonstrated a strong association with a reduced risk of death within 36 months post-IS.
Conclusions:
- Treatment of IS with intravenous recombinant tissue plasminogen activator is associated with improved three-year survival.
- Age and stroke severity are key factors influencing long-term outcomes after IS.
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