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Published on: October 10, 2025
[Infection and infertility]
A Pilatz1, M Boecker2, H-C Schuppe2
1Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Rudolf-Buchheim-Str. 7, 35392, Gießen, Deutschland. adrian.pilatz@chiru.med.uni-giessen.de.
Urogenital tract infections are a significant cause of male infertility, affecting 6-10% of men seeking fertility treatment. This review details key infections and their impact on male reproductive health.
Area of Science:
- Reproductive Medicine
- Urology
- Infectious Diseases
Background:
- Urogenital tract infections are established causes of male infertility.
- Epidemiological data show 6-10% of males evaluated for infertility have an infectious cause.
Purpose of the Study:
- To provide a comprehensive review of significant urogenital tract infections in males.
- To examine the impact of these infections on male fertility.
- To present evidence for infectious etiologies in infertile males.
Main Methods:
- Literature review of urogenital tract infections and male infertility.
- Synthesis of epidemiological data on infectious causes of infertility.
- Analysis of the impact of prostatitis, epididymitis, orchitis, and male accessory gland infections (MAGI) on fertility.
Main Results:
- Prostatitis, epididymitis, orchitis, and MAGI are key urogenital infections impacting male fertility.
- A significant proportion of infertile males have an identifiable infectious etiology.
- Evidence supports a causal link between specific infections and reduced male reproductive capacity.
Conclusions:
- Infections of the urogenital tract represent a critical factor in male infertility.
- Understanding these infections is crucial for diagnosing and managing male reproductive health issues.
- Further research into the mechanisms and treatments of infection-induced male infertility is warranted.
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