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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Infertility in Males01:23

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
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[Infection and infertility].

A Pilatz1, M Boecker2, H-C Schuppe2

  • 1Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Rudolf-Buchheim-Str. 7, 35392, Gießen, Deutschland. adrian.pilatz@chiru.med.uni-giessen.de.

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|June 24, 2016
PubMed
Summary
This summary is machine-generated.

Urogenital tract infections are a significant cause of male infertility, affecting 6-10% of men seeking fertility treatment. This review details key infections and their impact on male reproductive health.

Keywords:
AzoospermiaEpididymitisOrchitisProstatitisUrogenital tract infections

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Area of Science:

  • Reproductive Medicine
  • Urology
  • Infectious Diseases

Background:

  • Urogenital tract infections are established causes of male infertility.
  • Epidemiological data show 6-10% of males evaluated for infertility have an infectious cause.

Purpose of the Study:

  • To provide a comprehensive review of significant urogenital tract infections in males.
  • To examine the impact of these infections on male fertility.
  • To present evidence for infectious etiologies in infertile males.

Main Methods:

  • Literature review of urogenital tract infections and male infertility.
  • Synthesis of epidemiological data on infectious causes of infertility.
  • Analysis of the impact of prostatitis, epididymitis, orchitis, and male accessory gland infections (MAGI) on fertility.

Main Results:

  • Prostatitis, epididymitis, orchitis, and MAGI are key urogenital infections impacting male fertility.
  • A significant proportion of infertile males have an identifiable infectious etiology.
  • Evidence supports a causal link between specific infections and reduced male reproductive capacity.

Conclusions:

  • Infections of the urogenital tract represent a critical factor in male infertility.
  • Understanding these infections is crucial for diagnosing and managing male reproductive health issues.
  • Further research into the mechanisms and treatments of infection-induced male infertility is warranted.