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Lithium-Induced Motor Neuropathy: An Unusual Presentation
Satyakam Mohapatra1, Manas Ranjan Sahoo1, Neelmadhav Rath1
1Department of psychiatry, Mental Health Institute, S.C.B. Medical College, Cuttack, Odisha, India.
Indian Journal of Psychological Medicine
|June 24, 2016
Summary
Lithium can cause peripheral neuropathy even at therapeutic levels. This case highlights motor neuropathy in a patient without lithium toxicity, suggesting a need for increased awareness.
Area of Science:
- Neurology
- Toxicology
- Pharmacology
Background:
- Peripheral neuropathy is a potential adverse effect of lithium treatment.
- Most reported cases involve lithium intoxication, making non-toxic neuropathy under-recognized.
Observation:
- A 26-year-old male presented with motor neuropathy.
- The patient was undergoing therapeutic lithium treatment.
Findings:
- The patient exhibited motor neuropathy despite having a normal, therapeutic lithium blood level.
- This suggests lithium can induce neuropathy independent of toxicity.
Implications:
- Clinicians should consider lithium-induced neuropathy in patients with neurological symptoms, even with therapeutic levels.
- This case broadens the understanding of lithium's neurotoxic potential.
- Further research is needed to elucidate the mechanisms of non-toxic lithium neuropathy.
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