Related Experiment Video

Updated: Jul 3, 2026

Stereotaxic Injection of a Viral Vector for Conditional Gene Manipulation in the Mouse Spinal Cord
08:39

Stereotaxic Injection of a Viral Vector for Conditional Gene Manipulation in the Mouse Spinal Cord

Published on: March 18, 2013

32.2K

Viral-mediated gene therapy for spinal cord injury (SCI) from a translational neuroanatomical perspective

Andrew P Tosolini1, Renée Morris2

  • 1Translational Neuroscience Facility, School of Medical Sciences, the University of New South Wales (UNSW Australia), Sydney, Australia; Current address for Tosolini AP: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK.

Neural Regeneration Research
|June 24, 2016
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Adeno-associated Virus-mediated Transgene Expression in Genetically Defined Neurons of the Spinal Cord08:41

Adeno-associated Virus-mediated Transgene Expression in Genetically Defined Neurons of the Spinal Cord

Published on: May 12, 2018

19.0K
Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery07:27

Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery

Published on: June 30, 2021

2.7K

Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...