Related Experiment Video
Updated: Mar 19, 2026
06:12
Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition
Published on: March 3, 2023
1.4K
Hormonal Perturbations in Occupationally Exposed Nickel Workers
Safia Beshir1, Khadiga Salah Ibrahim1, Weam Shaheen1
1Environmental and Occupational Medicine Department, National Research Centre, Dokki, Giza, Egypt.
Open Access Macedonian Journal of Medical Sciences
|June 24, 2016
Summary
Occupational nickel exposure disrupts male reproductive hormones, leading to significant increases in sexual dysfunction among exposed workers. This study highlights nickel
Area of Science:
- Environmental Health
- Endocrinology
- Occupational Medicine
Background:
- Nickel is a recognized endocrine disruptor with known adverse reproductive effects.
- Occupational exposure to nickel poses a risk to reproductive health.
Purpose of the Study:
- Investigate testiculo-hormonal perturbations in workers occupationally exposed to nickel.
- Assess the impact of nickel exposure on human male sexual function.
Main Methods:
- Cross-sectional comparative study of 105 electroplating workers exposed to nickel and 60 controls.
- Measured serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone levels.
- Determined urinary nickel concentrations.
Main Results:
- Exposed workers showed significantly higher serum LH, FSH, and urinary nickel levels compared to controls.
- Incidence of multiple sexual disorders was significantly higher in nickel-exposed workers.
- Specific sexual disorders (decreased libido, impotence, premature ejaculation) were 9.5, 5.1, and 4.4 folds higher, respectively, in exposed workers.
Conclusions:
- Occupational nickel exposure induces significant testiculo-hormonal perturbations.
- Nickel exposure is linked to a higher prevalence of male sexual dysfunction.
Related Concept Videos
01:27Psychoneuroimmunology: Cardiovascular Disease
653
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
653
01:23Drugs Acting on Autonomic Ganglia: Stimulants
2.2K
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
2.2K
01:03Precipitation Gravimetry
16.0K
Precipitation gravimetry is based on converting an analyte into a sparingly soluble precipitate, which is separated by filtration and weighed. An ideal precipitate should be pure, insoluble, of known composition, and easily filtered from the reaction mixture.
In determining nickel by gravimetric analysis, a precipitant of ethanolic dimethylglyoxime is added to a hot nickel salt solution. This is quickly followed by the dropwise addition of dilute ammonia solution until precipitation occurs. A...
In determining nickel by gravimetric analysis, a precipitant of ethanolic dimethylglyoxime is added to a hot nickel salt solution. This is quickly followed by the dropwise addition of dilute ammonia solution until precipitation occurs. A...
16.0K