Salbutamol Abuse is Associated with Ventricular Fibrillation

Area of Science:

• Cardiology
• Toxicology
• Emergency Medicine

Background:

• Salbutamol, a beta-2 adrenergic agonist, is commonly used for asthma treatment.
• Cardiac complications associated with salbutamol use, particularly in overdose, are a known concern.

Observation:

• A 24-year-old female presented after a significant salbutamol overdose (76 mg) with suicidal intent.
• The patient developed life-threatening cardiac arrhythmias, specifically supraventricular tachycardia and ventricular fibrillation.

Findings:

• Defibrillation was successful in restoring regular sinus rhythm.
• The patient experienced hypokalemia, a common electrolyte disturbance in salbutamol toxicity.
• Hospitalization in the intensive care unit was required for monitoring and management.

Implications:

• This case highlights the critical risk of severe cardiac events following massive salbutamol ingestion.
• It underscores the importance of immediate medical intervention, including advanced cardiac life support, in managing salbutamol overdose.
• Awareness of potential cardiac toxicity is essential for clinicians managing patients with suspected salbutamol abuse.