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Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

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Hydrolyzed Proteins in Preterm Infants.

Thibault Senterre, Jacques Rigo

Nestle Nutrition Institute Workshop Series

|June 24, 2016

Summary

This summary is machine-generated.

Hydrolyzed proteins in infant formula may not be as effective for preterm infants, potentially requiring higher protein content for adequate weight gain. Further research is needed to confirm benefits and safety.

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Area of Science:

Neonatal Nutrition
Pediatric Gastroenterology
Dietary Protein Research

Background:

Milk proteins are crucial for preterm infants with high nutritional demands.
Hydrolyzed proteins (HPs) in infant formulas (HPFs) are used for gastrointestinal and allergic condition management.
Previous studies have investigated HP adequacy in preterm infants.

Purpose of the Study:

To evaluate the adequacy and impact of hydrolyzed proteins in preterm infant formulas.
To assess protein utilization, weight gain, and tolerance with HPFs.
To explore the potential preventive effects of HPFs on allergic diseases in preterm infants.

Main Methods:

Comparative analysis of protein utilization and efficiency between HPFs and intact protein formulas.
Evaluation of weight gain and nutrient absorption in preterm infants fed HPFs.
Assessment of gastrointestinal transit time, stool consistency, and feeding tolerance.

Main Results:

Protein utilization and efficiency are generally lower with HPFs compared to intact protein formulas.
Lower weight gain is observed with HPFs, often necessitating a 10% protein increase.
Mineral absorption, including trace elements and vitamins, may be reduced; data are limited.
HPFs can accelerate gastrointestinal transit and soften stools, but benefits to feeding tolerance are unclear.
Preterm infants face similar allergy risks as term infants, but HPF's preventive role is under-researched.

Conclusions:

Most modern HPFs for preterm infants are well-tolerated with adjusted nutrient content.
The demonstrated benefits and safety of HPFs in preterm infants require further high-quality studies.
More research is essential to confirm the efficacy and safety of hydrolyzed protein formulas for preterm infants.