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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Antiphospholipid Antibodies in Lupus Nephritis
Ioannis Parodis1, Laurent Arnaud1, Jakob Gerhardsson1
1Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Plos One
|June 24, 2016
Summary
Antiphospholipid antibodies (aPL) do not cause lupus nephritis (LN) in systemic lupus erythematosus (SLE). However, IgG aPL may temporarily worsen kidney function in LN patients, with levels decreasing after treatment in responders.
Area of Science:
- Nephrology
- Rheumatology
- Immunology
Background:
- Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE).
- The role of antiphospholipid antibodies (aPL) in the pathogenesis and progression of LN remains incompletely understood.
Purpose of the Study:
- To investigate the impact of aPL on short-term and long-term renal outcomes in patients with LN.
- To assess the relationship between aPL and renal function markers in SLE patients with and without LN.
Main Methods:
- Cross-sectional analysis of aPL in SLE patients with and without LN.
- Prospective study of aPL levels before and after induction treatment in patients with active LN.
- Evaluation of long-term renal outcomes using estimated glomerular filtration rate (eGFR) and Chronic Kidney Disease (CKD) stage.
Main Results:
- No association found between aPL and the occurrence of LN in SLE patients.
- IgG aPL positivity was linked to higher creatinine levels and short-term renal impairment in active LN patients.
- aPL levels decreased post-treatment only in responders, indicating response-dependent modulation by immunosuppressive drugs.
- No significant association between aPL and long-term renal outcomes (eGFR, CKD stage) was observed.
Conclusions:
- aPL positivity and levels are not associated with the development of LN.
- IgG aPL may be associated with short-term renal function decline in LN, but does not impact long-term renal outcomes.
- aPL levels are influenced by immunosuppressive therapy in an outcome-dependent manner.
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