Properties of genetic instability during the vegetative growth of Coprinus radiatus

In Coprinus radiatus, a mutation at the Nic-2 locus unstable at meiosis has been previously described. Further studies have now shown that this mutation is also unstable, although with lower frequency, during vegetative growth. This 'vegetative instability', which is thermosensitive, is not a random process but an aggregative process, perhaps depending on the physiological state of the mycelium.