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Updated: Mar 19, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

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Coexistence of Ureaplasma and chorioamnionitis is associated with prolonged mechanical ventilation

Euiseok Jung1, Chang Won Choi2,3, Su Yeong Kim4

  • 1Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, Korea.

Pediatrics International : Official Journal of the Japan Pediatric Society
|June 24, 2016
PubMed

Insights

Maternal histologic chorioamnionitis (HCAM) and Ureaplasma infection together significantly increase the risk of prolonged mechanical ventilation for extremely low-birthweight (ELBW) infants. This combined exposure poses a serious threat to respiratory health in vulnerable newborns.

Area of Science:

  • Neonatalogy
  • Perinatal Medicine
  • Infectious Diseases

Background:

  • Histologic chorioamnionitis (HCAM) and Ureaplasma infection are linked to perinatal lung injury.
  • The combined impact of HCAM and Ureaplasma on extremely low-birthweight (ELBW) infants requires further investigation.

Purpose of the Study:

  • To test the hypothesis that coexisting maternal HCAM and perinatal Ureaplasma exposure elevates the risk of prolonged mechanical ventilation in ELBW infants.

Main Methods:

  • A retrospective cohort study included ELBW infants born between 2008-2013.
  • Placental pathology (HCAM) and gastric fluid Ureaplasma detection (culture, PCR) were analyzed.
  • Prolonged mechanical ventilation was defined as ventilation initiated within 28 days and continued.

Main Results:

  • Of 111 ELBW infants, 18 (21.4%) had both HCAM and Ureaplasma exposure.
  • Seven infants (8.3%) required mechanical ventilation beyond 36 weeks postmenstrual age (PMA).
  • Combined HCAM and Ureaplasma exposure was significantly associated with prolonged mechanical ventilation (OR, 8.7; 95% CI: 1.1-67.2) after adjustments.

Conclusions:

  • Coexistence of maternal HCAM and perinatal Ureaplasma exposure significantly increases the risk of prolonged mechanical ventilation in ELBW infants.
  • This finding highlights the critical importance of identifying and managing these co-occurring conditions in high-risk neonates.
Abstract

Keywords:
Ureaplasma infectionbronchopulmonary dysplasiachorioamnionitisextremely low-birthweightinfant

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