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Bronchoconstriction-triggered cough in atopic cough: A retrospective study
Noriyuki Ohkura1, Johsuke Hara1, Tamami Sakai1
1a Department of Respiratory Medicine and Cellular Transplantation Biology , Graduate School of Medical Sciences, Kanazawa University , Kanazawa , Ishikawa , Japan.
Experimental Lung Research
|June 24, 2016
Summary
Atopic cough (AC) patients exhibit a reduced cough response to bronchoconstriction compared to cough variant asthma (CVA) patients. This difference may aid in diagnosing chronic cough conditions.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Respiratory Medicine
Background:
- Atopic cough (AC) and cough variant asthma (CVA) are leading causes of chronic non-productive cough.
- CVA is characterized by an exaggerated cough reflex to bronchoconstriction.
- The cough response to bronchoconstriction in AC is not well understood.
Purpose of the Study:
- To compare methacholine (Mch)-induced cough in AC and CVA.
- To investigate the diagnostic utility of cough response to bronchoconstriction in differentiating AC from CVA.
Main Methods:
- Diagnoses of AC and CVA were established using clinical history, physical examination, bronchodilator response, capsaicin cough reflex sensitivity, spirometry, and methacholine airway responsiveness.
- Methacholine-induced cough was measured in 13 AC patients and 12 CVA patients.
Main Results:
- AC patients showed a significantly lower number of coughs (1/32 min) following Mch inhalation compared to CVA patients (35.5/32 min).
- The Mch challenge induced milder bronchoconstriction (PC35-PEF40) than typically used for asthma diagnosis (PC20-FEV1).
Conclusions:
- The cough response to bronchoconstriction is diminished in AC relative to CVA.
- This differential cough response may serve as a valuable diagnostic marker for chronic cough.
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