Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.3K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.3K
Colonisation of Pathogens01:25

Colonisation of Pathogens

9
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
9
Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

1
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
1
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

3
Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
3
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

1
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
1
Bacterial Toxins01:12

Bacterial Toxins

2
Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...
2

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Intensive Physician Coaching-as-Communication Curriculum to Promote a Culture of Coaching: A Pilot Program to Assess Feasibility and Acceptability in Faculty and Residents.

Journal of medical education and curricular development·2025
Same author

IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity.

Cell reports·2025
Same author

Assessing Program Culture in Virtual Fellowship Interviews: Insights From Pulmonary and Critical Care Fellows.

Cureus·2025
Same author

A Rare Case of Recurrent Renal Infarcts With Unique Etiologies in Different Kidneys Occurring Six Years Apart.

Case reports in nephrology·2024
Same author

Transient Hyperglycemia in a Patient With Type 2 Diabetes After COVID-19 Messenger RNA Vaccination: A Case Report.

Cureus·2024
Same author

Norovirus NS1/2 protein increases glutaminolysis for efficient viral replication.

PLoS pathogens·2024
Same journal

Muc16 contributes to protection against invasive pneumococcal infection originating from nasal colonization.

Microbiology spectrum·2026
Same journal

Tail-specific protease (Tsp)-mediated envelope remodeling and beta-lactam tolerance in <i>Escherichia coli</i>.

Microbiology spectrum·2026
Same journal

Comparative evaluation of EUCAST RAST and QuickMIC for rapid antimicrobial susceptibility testing of carbapenem-resistant organisms directly from positive blood cultures.

Microbiology spectrum·2026
Same journal

Systematic discovery of novel phosphoinositide-binding effectors in <i>Legionella</i> reveals conserved É‘-helical folds.

Microbiology spectrum·2026
Same journal

ZILA-SRM: a probabilistic framework with zero-inflated latent models for robust strain reconstruction from metagenomes.

Microbiology spectrum·2026
Same journal

Emergence and persistence of ESBL- and carbapenemase-producing <i>Klebsiella pneumoniae</i>-related species in Barcelona wastewater treatment plants.

Microbiology spectrum·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

1.0K

Bacterial Metabolism Shapes the Host-Pathogen Interface.

Karla D Passalacqua1, Marie-Eve Charbonneau1, Mary X D O'Riordan1

  • 1Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.

Microbiology Spectrum
|June 24, 2016
PubMed
Summary
This summary is machine-generated.

Bacterial pathogens utilize diverse metabolic strategies to thrive in the human body, adapting to nutrient availability and immune defenses for survival and replication.

More Related Videos

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.9K
Using Coculture to Detect Chemically Mediated Interspecies Interactions
08:29

Using Coculture to Detect Chemically Mediated Interspecies Interactions

Published on: October 31, 2013

14.1K

Related Experiment Videos

Last Updated: Mar 19, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

1.0K
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.9K
Using Coculture to Detect Chemically Mediated Interspecies Interactions
08:29

Using Coculture to Detect Chemically Mediated Interspecies Interactions

Published on: October 31, 2013

14.1K

Area of Science:

  • Microbiology
  • Metabolic pathways
  • Host-pathogen interactions

Background:

  • Bacterial pathogens exploit human hosts for nutrients.
  • Metabolic pathways for colonization are varied and flexible.
  • Host immune pressures shape bacterial nutrient acquisition.

Purpose of the Study:

  • To explore bacterial carbon and energy metabolism within the host.
  • To understand nutrient acquisition strategies for pathogen replication.
  • To investigate how bacteria use nutrients for immune evasion.

Main Methods:

  • Review of current literature on bacterial metabolism in hosts.
  • Analysis of metabolic pathways employed by various bacterial pathogens.
  • Examination of nutrient utilization in different host niches.

Main Results:

  • Bacterial pathogens exhibit significant metabolic flexibility.
  • Distinct host niches impose specific nutrient acquisition challenges.
  • Metabolic strategies are crucial for bacterial replication and immune evasion.

Conclusions:

  • Understanding bacterial metabolism is key to combating infections.
  • Targeting nutrient acquisition pathways offers potential therapeutic strategies.
  • Bacterial metabolic adaptability is central to pathogenesis.