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Tumor-Induced Myeloid-Derived Suppressor Cells

Francesco De Sanctis1, Vincenzo Bronte1, Stefano Ugel1

  • 1Immunology Section, Department of Pathology and Diagnostics, University of Verona, 37135, Verona, Italy.

Microbiology Spectrum
|June 24, 2016
PubMed

Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous, immune-suppressive leukocyte population that develops systemically and infiltrates tumors. MDSCs can restrain the immune response through different mechanisms including essential metabolite consumption, reactive oxygen and nitrogen species production, as well as display of inhibitory surface molecules that alter T-cell trafficking and viability. Moreover, MDSCs play a role in tumor progression, acting directly on tumor cells and promoting cancer stemness, angiogenesis, stroma deposition, epithelial-to-mesenchymal transition, and metastasis formation. Many biological and pharmaceutical drugs affect MDSC expansion and functions in preclinical tumor models and patients, often reversing host immune dysfunctions and allowing a more effective tumor immunotherapy.

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