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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
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Candida-Bacteria Interactions: Their Impact on Human Disease

Devon L Allison1,2, Hubertine M E Willems3, J A M S Jayatilake4

  • 1Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland-Baltimore, Baltimore, MD 21201.

Microbiology Spectrum
|June 24, 2016
PubMed

Insights

Candida albicans, a common fungal pathogen, frequently interacts with bacteria in polymicrobial infections. Understanding these trans-kingdom interactions is crucial for managing infections, especially with rising antimicrobial resistance.

Area of Science:

  • Mycology
  • Microbiology
  • Infectious Diseases

Background:

  • Candida species, particularly Candida albicans, are leading causes of human fungal infections.
  • Candida albicans contributes to polymicrobial infections, interacting with various bacterial species.
  • These interactions influence virulence, pathogenicity, and host immune responses.

Purpose of the Study:

  • To explore the current literature on interactions between Candida and clinically important bacteria.
  • To evaluate these interactions in the context of pathogenesis, diagnosis, and disease management.
  • To highlight the need for understanding intermicrobial cross-talk in treating Candida-associated polymicrobial infections.

Main Methods:

  • Literature review of studies on Candida-bacteria interactions.
  • Analysis of polymicrobial biofilm virulence mechanisms (adhesion, invasion, quorum sensing, antimicrobial resistance).
  • Evaluation of trans-kingdom interactions' impact on pathogenicity and host immunity.

Main Results:

  • Candida-bacteria interactions can be synergistic or antagonistic, modulating virulence.
  • Polymicrobial biofilms exhibit complex virulence mechanisms.
  • Understanding these interactions is vital for developing effective treatment strategies.

Conclusions:

  • Interactions between Candida and bacteria significantly impact infection dynamics.
  • Further research into Candida-bacteria cross-talk is essential for advancing diagnostics and therapeutics.
  • Addressing antimicrobial and antifungal resistance necessitates a focus on polymicrobial infection management.

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