Related Experiment Video

Updated: Mar 19, 2026

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
06:24

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

15.8K

Mathematical Models of Contrast Transport Kinetics for Cancer Diagnostic Imaging: A Review

Simona Turco, Hessel Wijkstra, Massimo Mischi

    IEEE Reviews in Biomedical Engineering
    |June 24, 2016
    PubMed

    Insights

    Quantitative imaging techniques like dynamic contrast-enhanced MRI, CT, and ultrasound help assess tumor angiogenesis. These methods evaluate microvascular changes for improved cancer diagnosis and treatment monitoring.

    Area of Science:

    • Oncology
    • Medical Imaging
    • Biomedical Engineering

    Background:

    • Angiogenesis is crucial for tumor growth and metastasis.
    • Targeting angiogenesis is a key strategy in novel cancer therapies.
    • Early cancer diagnosis and monitoring treatment response are critical.

    Purpose of the Study:

    • To review quantitative imaging methods for assessing tumor angiogenesis.
    • To highlight the role of dynamic contrast-enhanced imaging in evaluating microvasculature.
    • To discuss the application of these techniques in cancer diagnosis and therapy monitoring.

    Main Methods:

    • Dynamic contrast-enhanced imaging (MRI, CT, ultrasound).
    • Mathematical modeling of contrast agent kinetics.
    • Quantitative assessment of microvascular structural and functional changes.

    Main Results:

    • Dynamic contrast-enhanced imaging allows noninvasive assessment of angiogenesis.
    • Mathematical modeling provides quantitative insights into microvascular changes.
    • These imaging modalities aid in evaluating tumor angiogenesis.

    Conclusions:

    • Quantitative imaging is vital for understanding tumor angiogenesis.
    • Advanced imaging techniques support cancer diagnosis and therapeutic response evaluation.
    • Dynamic contrast-enhanced imaging with mathematical modeling offers robust assessment of tumor microvasculature.

    More Related Videos

    Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers12:24

    Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

    Published on: July 17, 2012

    12.9K
    Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning10:25

    Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

    Published on: April 12, 2024

    2.6K

    Related Concept Videos

    Pharmacokinetic Models: Comparison and Selection Criterion01:26

    Pharmacokinetic Models: Comparison and Selection Criterion

    Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
    Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
    446
    Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

    Imaging Studies II: Positron Emission Tomography and Scintigraphy

    Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
    Fundamental Principles of PET
    721
    Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

    Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

    Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
    426