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Related Concept Videos

Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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Mitochondrial Membranes01:45

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A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
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Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
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Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging?

Xiaomin Zhang1, Emmanuel D Williams1, Gohar Azhar1

  • 1Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.

Experimental Gerontology
|June 25, 2016
PubMed
Summary
This summary is machine-generated.

The transcriptional regulator p49/STRAP (SRFBP1) increases with age, deacetylates histone H4K16, and impairs mitochondrial function, contributing to cardiac aging and senescence.

Keywords:
Histone acetylationMitochondrial oxygen consumptionMitofusinsPGC-1α

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Area of Science:

  • Molecular Biology
  • Cellular Aging
  • Cardiovascular Research

Background:

  • p49/STRAP (SRFBP1) is a transcriptional regulator linked to cardiac aging.
  • It possesses SRF and BUD22 domains, influencing cellular growth and size.
  • Previous observations suggest p49/STRAP affects intracellular NAD/NADH ratio and protein deacetylation.

Purpose of the Study:

  • To investigate the impact of p49/STRAP overexpression on histone acetylation and mitochondrial function.
  • To examine the expression levels of p49/STRAP in aging mouse hearts and human cells.

Main Methods:

  • Overexpression of p49/STRAP in cellular models.
  • Analysis of histone H4K16 acetylation.
  • Measurement of PGC-1α, mitofusin-1, and mitofusin-2 mRNA and protein levels.
  • Assessment of mitochondrial size, membrane potential, and oxygen consumption rate.
  • Quantification of p49/STRAP expression in aged mouse hearts and cultured HUVECs.

Main Results:

  • p49/STRAP overexpression led to histone H4K16 deacetylation.
  • Suppression of PGC-1α, mitofusin-1, and mitofusin-2 expression at both mRNA and protein levels.
  • Reduction in mitochondrial size, membrane potential, and oxygen consumption rate.
  • Increased p49/STRAP expression in aged mouse hearts and senescent HUVECs.

Conclusions:

  • Increased p49/STRAP expression in aging may promote histone deacetylation.
  • This can negatively impact mitochondrial dynamics and function, reducing cardiac performance during senescence.