Predictive value of plasma β2-microglobulin on human body function and senescence

Area of Science:

• Biochemistry
• Gerontology
• Clinical Diagnostics

Background:

• Plasma beta-2 microglobulin (β2-MG) is recognized as a potential senescence factor.
• Understanding its correlation with physiological functions is crucial for aging research.

Purpose of the Study:

• To investigate the relationship between plasma β2-MG levels and age.
• To explore the association of β2-MG with heart, liver, and kidney function.
• To evaluate β2-MG's predictive value for human metabolism and senescence.

Main Methods:

• Cross-sectional study involving 387 healthy individuals of varying ages.
• Plasma β2-MG levels measured using immunoturbidimetry via an automatic biochemical analyzer.
• Comprehensive analysis of biochemical indexes and correlation with β2-MG, age, and gender.

Main Results:

• A significant positive correlation was observed between plasma β2-MG and age (r = 0.373, p < 0.010).
• β2-MG showed significant negative correlation with HDL-C.
• Positive correlations were found between β2-MG and various markers including LP(a), BUN, CREA, UA, CYS-C, LDH, CK-MB, HBDH, AST, GLB, and HCY.

Conclusions:

• Plasma β2-MG is closely correlated with age and biochemical markers of heart, kidney, and liver function.
• β2-MG serves as a significant biomarker for human physiological function and anti-senescence.
• The findings support the basic research and clinical guidance value of β2-MG in aging and metabolic studies.