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Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
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Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist

Hannah M Stoveken1, Laura L Bahr1, M W Anders1

  • 1Department of Pharmacology and Physiology (H.M.S., L.L.B., M.W.A., A.P.W., A.V.S.), and Department of Anesthesiology (L.L.B., A.P.W.), University of Rochester Medical Center, Rochester, New York; and Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (G.G.T.).

Molecular Pharmacology
|June 25, 2016
PubMed
Summary

Researchers identified dihydromunduletone (DHM) as a novel antagonist for adhesion G protein-coupled receptors (aGPCRs). This small molecule shows potential for developing new therapeutics targeting these cancer-associated receptors.

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