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Updated: Mar 19, 2026

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Published on: May 11, 2017
Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions
Giovanna Bosica1, Roderick Abdilla2
1Department of Chemistry, University of Malta, Msida MSD 2080, Malta. giovanna.bosica@um.edu.mt.
Abstract:
Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.
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