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Mother and Infant Body Mass Index, Breast Milk Leptin and Their Serum Leptin Values

Francesco Savino1, Allegra Sardo2, Lorenza Rossi3

  • 1Department of Pediatrics, Regina Margherita Children' Hospital, Città della Salute e della Scienza di Torino, Piazza Polonia 94, Torino I-10126, Italy. francesco.savino@unito.it.

Nutrients
|June 25, 2016
PubMed

Insights

Maternal Body Mass Index (BMI) and breast milk leptin may influence infant serum leptin levels. This suggests potential links to infant obesity risk, warranting further investigation into genetic and environmental factors.

Area of Science:

  • Endocrinology
  • Pediatrics
  • Nutritional Science

Background:

  • Leptin, a key hormone in energy balance, plays a role in infant development.
  • Understanding factors influencing early infant leptin levels is crucial for assessing long-term obesity risk.

Purpose of the Study:

  • To examine the relationship between maternal and infant Body Mass Index (BMI).
  • To investigate correlations between serum leptin in mothers and infants.
  • To determine breast milk leptin concentration and its association with infant and maternal factors.

Main Methods:

  • Radioimmunoassay (RIA) was used to measure leptin in infant serum and maternal breast milk.
  • Maternal and infant anthropometric measurements, including BMI, were collected.
  • Serum leptin levels were analyzed in 58 healthy mother-infant pairs.

Main Results:

  • Infant serum leptin positively correlated with infant BMI and breast milk leptin.
  • Maternal serum leptin showed positive correlations with maternal BMI and breast milk leptin.
  • Specific median concentrations for infant serum, maternal serum, and breast milk leptin were established.

Conclusions:

  • Maternal BMI and breast milk leptin are potential influencers of infant serum leptin.
  • Further research is required to understand the interplay of genetics and environment in infant leptin production.
  • Investigating these factors may help elucidate the origins of obesity risk in later life.
Abstract

Keywords:
BMIbreast milkinfancymothersserum leptin

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