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Updated: Mar 19, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Tales of significance
1BMC Biology, BioMed Central, 236 Gray's Inn Road, London, WC1X 8HB, UK. BMCBiologyEditorial@biomedcentral.com.
Abstract:
In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the chemical, which they think might affect the male:female ratio compared with the untreated group. They claim that there is a statistically significant increase in the percentage of males produced and conclude that the drug affects sex ratios.
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