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Drug-associated acute kidney injury: who's at risk?

Emily L Joyce1, Sandra L Kane-Gill2,3,4,5, Dana Y Fuhrman1,4,6,5

  • 1Division of Nephrology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.

Pediatric Nephrology (Berlin, Germany)
|June 25, 2016
PubMed

Insights

Preventing acute kidney injury (AKI) in children is crucial, as effective treatments are lacking. Early identification of at-risk children and judicious use of nephrotoxic medications are key strategies.

Area of Science:

  • Pediatric Nephrology
  • Clinical Pharmacology

Background:

  • Acute kidney injury (AKI) incidence in children is rising.
  • Nephrotoxic medications significantly contribute to AKI development.
  • Current AKI treatments are limited, emphasizing prevention.

Purpose of the Study:

  • To highlight the importance of early identification of high-risk pediatric patients.
  • To discuss the role of judicious nephrotoxin use in AKI prevention.
  • To explore advancements in early AKI detection beyond serum creatinine.

Main Methods:

  • Review of current understanding of nephrotoxic medication impact on pediatric AKI.
  • Analysis of limitations in current AKI diagnostic markers (serum creatinine).
  • Evaluation of emerging biomarkers for early AKI detection.

Main Results:

  • Early detection of at-risk children is vital for AKI prevention.
  • New biomarkers show promise for detecting AKI before serum creatinine rises.
  • Improved early AKI detection facilitates better nephrotoxin management.

Conclusions:

  • Preventing pediatric AKI requires early risk identification and careful nephrotoxin management.
  • Biomarker testing is essential for early AKI detection and risk assessment.
  • Judicious use of nephrotoxins and proactive monitoring are critical for mitigating AKI severity.

Keywords:
Acute kidney injuryAdverse drug reactionsCritical illnessDrug-associatedDrug-related side effectsNephrotoxicPharmacovigilance

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