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Microparticles as biomarkers of venous thromboembolic events

Elena Campello1, Luca Spiezia1, Claudia M Radu1

  • 1Department of Medicine (DIMED), University of Padua, Padua, Italy.

Biomarkers in Medicine
|June 25, 2016
PubMed

Insights

Plasma microparticles (MPs) show potential as biomarkers for venous thromboembolism (VTE). Research explores their role in detecting and predicting VTE, guiding prevention strategies.

Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Medicine

Background:

  • Microparticles (MPs) are small membrane vesicles released from cells during activation or apoptosis.
  • Current detection methods for MPs face limitations, hindering clinical research.
  • A link between MPs and venous thromboembolism (VTE) has been established.

Purpose of the Study:

  • To review the potential of plasma MPs as biomarkers for acute unprovoked VTE.
  • To assess the predictive value of MPs for VTE in high-risk populations, particularly cancer patients.
  • To discuss the prognostic role of MPs in guiding VTE prevention protocols.

Main Methods:

  • Literature review of studies investigating microparticles and venous thromboembolism.
  • Analysis of mechanisms by which MPs influence thrombogenesis (phosphatidylserine exposure, tissue factor transport, inflammation-coagulation crosstalk).
  • Evaluation of current research on plasma MP detection and clinical applications.

Main Results:

  • MPs contribute to thrombogenesis through phosphatidylserine exposure and tissue factor carriage.
  • Intercellular communication mediated by MPs links inflammation and coagulation.
  • Plasma MPs are being investigated for their utility in VTE detection and risk stratification.

Conclusions:

  • Plasma microparticles hold promise as diagnostic and prognostic biomarkers for VTE.
  • Further research is needed to overcome detection limitations and validate MP-based VTE prevention strategies.
  • MPs may offer novel insights into VTE pathogenesis and personalized treatment approaches.
Keywords:
annexinbiomarkerscancerflow cytometrymicroparticlesmicrovesiclesthrombosistissue factor

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