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Denosumab: a case of MRONJ with resolution

C V Lyttle¹, H Patterson²

¹CT1.

British Dental Journal

|June 25, 2016

Summary

Denosumab, a bone-loss drug, can cause jaw healing problems after tooth extraction. Stopping the medication allowed the patient's jaw bone to heal.

Area of Science:

Oral surgery
Pharmacology
Oncology

Background:

Denosumab is an antiresorptive medication increasingly used for osteoporosis and cancer-related skeletal events.
It is an alternative to bisphosphonates, targeting the RANKL pathway.

Observation:

A patient on denosumab experienced a non-healing extraction socket in the lower jaw.
The condition persisted despite standard dental care.

Findings:

Discontinuation of denosumab led to successful mucosal coverage and healing of the jaw bone.
This suggests a direct link between denosumab therapy and impaired bone healing post-extraction.

Implications:

Clinicians should consider denosumab's potential side effects on jaw bone healing.
Careful patient selection and monitoring are crucial for patients undergoing invasive dental procedures while on denosumab.

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