Related Experiment Video
Updated: Mar 19, 2026
07:28
Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Published on: October 29, 2020
9.5K
Doxycycline-induced drug fever: a case report
Hai-Ling Yuan1, Ning-Wei Lu2, Hua Xie1
1a Department of Pharmacy , Anning Branch Lanzhou General Hospital Lanzhou Command , Lanzhou , Gansu , China ;
Infectious Diseases (London, England)
|June 25, 2016
Summary
Drug fever, a rare side effect of doxycycline, can occur without other symptoms. This case highlights doxycycline-induced fever in a patient treated for brucellosis, emphasizing underdiagnosis of this adverse drug reaction.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Medicine
Background:
- Drug fever is an underreported adverse drug reaction characterized by fever without other clinical signs.
- Doxycycline, a broad-spectrum tetracycline antibiotic, is rarely associated with drug fever.
Observation:
- A patient developed drug fever after 17 days of doxycycline therapy for brucellosis.
- The febrile reaction occurred in the absence of other symptoms suggestive of infection or other adverse events.
Findings:
- This case report documents a rare instance of drug fever induced by doxycycline.
- The findings underscore the potential for doxycycline to cause febrile reactions, even after prolonged treatment.
Implications:
- Increased clinical awareness is needed to recognize and report doxycycline-induced drug fever.
- Early identification of drug fever can prevent unnecessary investigations and guide appropriate patient management.
