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Hypertension and alterations in left ventricular structure and geometry in African Americans: the Jackson Heart Study

Marwah Abdalla1, John N Booth2, Keith M Diaz1

  • 1Department of Medicine, Columbia University Medical Center, New York, NY, USA.

Journal of the American Society of Hypertension : JASH
|June 25, 2016
PubMed

Insights

Hypertension significantly increases the risk of abnormal left ventricular (LV) structure in African Americans. This study found hypertension strongly associated with concentric hypertrophy, a concerning LV abnormality.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Public Health

Background:

  • African Americans (AAs) exhibit higher hypertension-related cardiovascular risks than whites.
  • Abnormal left ventricular (LV) structure may underlie these disparities.

Purpose of the Study:

  • To investigate the association between prevalent hypertension and LV structural abnormalities.
  • Specifically examining concentric remodeling (CR), eccentric hypertrophy, and concentric hypertrophy (CH) in AAs.

Main Methods:

  • Analysis of 4721 participants from the Jackson Heart Study.
  • Hypertension defined as clinic blood pressure ≥140/90 mm Hg or medication use.
  • Multivariable analysis adjusted for relevant covariates.

Main Results:

  • Prevalent hypertension was linked to increased odds of CR (OR=1.78), eccentric hypertrophy (OR=1.68), and CH (OR=3.86).
  • Concentric hypertrophy showed the strongest association with hypertension.
  • The findings were statistically significant after multivariable adjustment.

Conclusions:

  • Hypertension is significantly associated with abnormal LV structure in a population-based sample of African Americans.
  • Concentric hypertrophy is a particularly prevalent LV abnormality in hypertensive AAs.
  • These findings highlight the importance of hypertension management for preventing cardiac structural changes in this population.

Keywords:
Echocardiography

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