Researchers' perspectives on pediatric obesity research participant recruitment

Yasha Parikh1,2, Maryann Mason3,4, Karen Williams5

  • 1Central Michigan University College of Medicine, Mt Pleasant, MI, USA. Parik1ys@cmich.edu.

Insights

Recruiting for childhood obesity studies is challenging due to logistical, economic, and stigma-related barriers. Addressing these requires flexible scheduling, incentives, and community engagement to improve participation in vital pediatric obesity research.

Area of Science:

  • Pediatric obesity research
  • Clinical trial recruitment strategies

Background:

  • Childhood obesity rates have tripled in recent decades, posing significant public health and economic challenges.
  • Effective interventions are crucial, necessitating robust study recruitment, which is a persistent challenge, particularly in pediatric obesity research.

Purpose of the Study:

  • To identify and understand the barriers encountered in recruiting participants for childhood obesity studies.
  • To review and propose facilitators that can overcome these recruitment difficulties and enhance study enrollment.

Main Methods:

  • Conducted interviews with 11 childhood obesity researchers who were contacted from a pool of 24.
  • Employed a Grounded Theory approach for this exploratory study, analyzing transcribed interviews using content analysis.
  • Utilized 28 codes for interview analysis by investigators YP and MM.

Main Results:

  • Identified recruitment barriers including family/study logistics, economic factors, provider disinterest, invasive protocols, stigma, time constraints, lack of patient motivation, classroom groupthink, and participant weight status denial.
  • Facilitators for enhanced recruitment include flexible scheduling (outside clinic hours), participant incentives, pre-study relationship building with communities/schools/clinics, highlighting patient benefits, and framing study focus on health rather than obesity.

Conclusions:

  • Pediatric obesity researchers face a combination of general clinical research, pediatric-specific, and obesity-specific recruitment challenges.
  • Awareness of these unique difficulties and the application of identified facilitators can improve recruitment efficiency and enrollment in pediatric obesity studies.
Abstract

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
357
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
647
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.6K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
313
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
11.1K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
269