Expression and clinicopathological correlations of retinoid acid receptor responder protein 1 in renal cell carcinomas
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Updated: Mar 19, 2026

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Annette Zimpfer1,2, Friedericke Dammert1, Aenne Glass3
1Institute of Pathology, University Medicine Rostock, Strempelstr. 14, 18055 Rostock, Germany.
Aim:
To evaluate the expression and prognostic value of RARRES1 at protein level in renal cell carcinoma (RCC).
Materials & Methods:
Expression profile of RARRES1 was analyzed in 903 documented RCC followed by clinicopathological correlations and survival analysis.
Results:
RARRES1 expression was seen in 72.5% of RCC. A stronger RARRES1 expression was seen in high grade compared with low grade RCC (p < 0.001). Logrank tests revealed shorter overall survival in RARRES1 positive RCC (p = 0.006) and in pT1/2 tumors with RARRES1 expression (p = 0.002).
Conclusion:
The variable expression profile in low and high grade RCC may reflect and confirm the differences of previous gene expression analysis. There was a significant prognostic value of RARRES1 expression in patients with RCC, especially in pT1/2 tumors.
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