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Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr(-/-) mice
Paulette A Krishack1, Timothy J Sontag2, Godfrey S Getz1,2
1Molecular Pathogenesis and Molecular Medicine Graduate Program, University of Chicago, IL, USA.
Abstract:
We previously showed that feeding a Western-type diet (WTD) to Ldlr(-/-) mice lacking serum amyloid A (SAA) (Saa(-/-) Ldlr(-/-) mice), the level of total blood monocytes was higher than in Ldlr(-/-) mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa(-/-) Ldlr(-/-) mice compared to Ldlr(-/-) mice and lower levels of GMP cells and CMP cells in Ldlr(-/-) mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice.
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