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Intraocular human thrombin infusion in diabetic vitrectomies
1Institute of Ophthalmology, University of Nijmegen, The Netherlands.
Ophthalmic Surgery
|April 1, 1989
Summary
Intravitreal thrombin infusion effectively reduced bleeding during vitrectomy in diabetic patients with proliferative vitreoretinopathy. Human thrombin showed promise for facilitating surgery with minimal inflammation.
Area of Science:
- Ophthalmology
- Vascular Surgery
- Diabetic Retinopathy
Background:
- Persistent vitreous hemorrhages and severe proliferative vitreoretinopathy pose surgical challenges in diabetic patients.
- Managing intraocular bleeding during vitrectomy is crucial for successful surgical outcomes.
Purpose of the Study:
- To prospectively evaluate the effectiveness of intravitreal thrombin infusion during vitrectomy.
- To assess the impact of human thrombin on surgical bleeding and postoperative inflammation.
Main Methods:
- Eight diabetic patients with persistent vitreous hemorrhages underwent vitrectomy with intravitreal thrombin infusion.
- A concentration of 80 units/ml of human thrombin in BSS-plus was administered.
- Bleeding time and postoperative media clarity were recorded.
Main Results:
- Intravitreal thrombin infusion significantly reduced intraoperative bleeding, with a mean bleeding time of 5 seconds.
- Postoperative vitreous clarity was achieved in 5 out of 8 patients by day one and 6 out of 8 by one month.
- No additional postoperative intraocular inflammation was observed.
Conclusions:
- Human thrombin infusion is an effective adjunct for controlling vitreous hemorrhage during vitrectomy.
- This method facilitates surgical procedures and appears to cause less inflammation compared to bovine thrombin.