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Evaluating Instantaneous Perfusion Responses of Parotid Glands to Gustatory Stimulation Using
T-W Chiu1,2, Y-J Liu2, H-C Chang3
1From the Departments of Radiology (T.-W.C., C.-W.W., H.-H.H., C.-J.J.).
AJNR. American Journal of Neuroradiology
|June 25, 2016
Summary
High-temporal-resolution echo-planar diffusion-weighted imaging (DWI) effectively quantifies parotid gland perfusion responses to gustatory stimulation. Apparent diffusion coefficient (ADC) changes reveal instantaneous functional changes in parotid glands.
Area of Science:
- Medical Imaging
- Radiology
- Physiology
Background:
- Parotid glands rapidly secrete saliva after gustatory stimulation.
- The role of diffusion-weighted imaging (DWI) temporal resolution in parotid gland function is unclear.
Purpose of the Study:
- Design a high-temporal-resolution echo-planar DWI sequence.
- Evaluate instantaneous MR perfusion responses of parotid glands to gustatory stimulation.
Main Methods:
- 21 healthy volunteers underwent echo-planar DWI (4 s/scan temporal resolution) on a 1.5T scanner.
- T2WI and DWI were qualitatively assessed; signal intensity and ADC were quantitatively analyzed.
- Statistical analysis used one-way ANOVA with post hoc Bonferroni correction.
Main Results:
- High interobserver agreement (κ ≥ 0.656) was achieved.
- Increased apparent diffusion coefficient (ADC) and reduced signal intensity on T2WI/DWI occurred immediately after lemon juice stimulation.
- ADC changes (24.8% ± 10.8%) were significantly greater than T2WI changes (-10.1% ± 5.2%) (P < .001).
Conclusions:
- High-temporal-resolution echo-planar DWI can quantify instantaneous parotid gland perfusion responses to gustatory stimulation.
- Apparent diffusion coefficient (ADC) is a sensitive marker for these functional changes.
