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Draft Genome Sequence and Gene Annotation of the Uropathogenic Bacterium Proteus mirabilis Pr2921

F M Giorello1, V Romero2, J Farias3

  • 1Department of Genomics, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.

Genome Announcements
|June 25, 2016
PubMed

Insights

We sequenced the genome of Proteus mirabilis Pr2921, a bacterium causing urinary tract infections. This revealed unique fimbrial genes, including extra copies of ucaA, potentially impacting infection severity.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Proteus mirabilis is a significant cause of complicated urinary tract infections.
  • Understanding the genetic basis of uropathogenic strains is crucial for developing effective treatments.

Purpose of the Study:

  • To report the complete genome sequence of the uropathogenic Proteus mirabilis strain Pr2921.
  • To identify unique genetic features, particularly fimbrial genes, that may contribute to its virulence.

Main Methods:

  • Whole-genome sequencing of Proteus mirabilis Pr2921.
  • Bioinformatic gene annotation and comparative genomic analysis.

Main Results:

  • The genome sequence of P. mirabilis Pr2921 was successfully obtained and annotated.
  • Two additional copies of the ucaA gene, encoding a key fimbrial protein, were identified.
  • Other fimbriae-related proteins not found in P. mirabilis HI4320 were also detected.

Conclusions:

  • The genome of P. mirabilis Pr2921 harbors unique genetic elements, including multiple ucaA copies.
  • These genetic differences may play a role in the pathogenesis of severe urinary tract infections caused by this strain.

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