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Updated: Mar 19, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

Inflammatory Disequilibrium in Stroke.

Danica Petrovic-Djergovic¹, Sascha N Goonewardena¹, David J Pinsky²

¹From the Departments of Internal Medicine (D.P.-D., S.N.G., D.J.P.) and Molecular and Integrative Physiology (D.J.P.), University of Michigan, Ann Arbor.

Circulation Research

|June 25, 2016

Summary

This summary is machine-generated.

Stroke activates the brain's immune system, influencing both injury and repair. Understanding this neuroimmune axis is key to developing new stroke therapies and improving patient outcomes.

Keywords:

CD39; CD73 adaptive immunity blood–brain barrier brain ischemia inflammation innate immunity

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Area of Science:

Neuroscience
Immunology
Pathophysiology

Background:

Significant advancements in stroke pathophysiology understanding.
Thrombolytic therapy is the standard for ischemic stroke, but novel therapeutic targets are needed.
The role of the immune system in central nervous system injury and repair after stroke is increasingly recognized.

Purpose of the Study:

To explore the frontiers of current knowledge on innate and adaptive immune responses in the brain during ischemic stroke.
To elucidate how neuroimmune activation impacts the initiation, propagation, and resolution phases of ischemic brain injury.
To highlight the necessity of expanding mechanistic understanding of the neuroimmune axis for stroke treatment.

Main Methods:

Review of current molecular biological techniques.
Analysis of advanced translational stroke models.
Examination of clinical studies on stroke pathophysiology and immune responses.

Main Results:

Stroke triggers activation of the neuroimmune axis, involving resident immune cells and recruited effector cells.
Neuroimmune activation directly influences all phases of ischemic brain injury.
Perturbation of immune equilibrium by stroke is implicated in both central nervous system injury and repair.

Conclusions:

Modulating local and systemic immune responses presents a potential therapeutic opportunity in stroke.
A deeper mechanistic understanding of the neuroimmune axis is crucial for developing effective stroke therapies.
Innate and adaptive immune responses in the brain play a significant role in shaping the course of ischemic stroke.