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Survivin: a unique target for tumor therapy
Himani Garg1, Prerna Suri2, Jagdish C Gupta3
1Amity Institute of Virology and Immunology, Amity University Uttar Pradesh, J-3 Block, Room No: LG21, Sector 125, Noida, Uttar Pradesh 201303 India.
Cancer Cell International
|June 25, 2016
Summary
Survivin, a protein regulating cell death and proliferation, is crucial in cancer development and stem cell maintenance. Targeting Survivin offers potential for novel cancer therapies and vaccines.
Area of Science:
- Molecular Biology
- Cancer Biology
- Stem Cell Biology
Background:
- Survivin is the smallest Inhibitor of Apoptosis (IAP) protein.
- It regulates apoptosis, cell cycle, proliferation, and cell death.
- Survivin is expressed in embryonic development and stem cells but typically absent in normal adult tissues.
Purpose of the Study:
- To review Survivin's diverse biological roles.
- To discuss its involvement in cancer progression, chemo-resistance, and stem cell biology.
- To explore therapeutic strategies targeting Survivin.
Main Methods:
- Literature review of Survivin's functions and expression.
- Analysis of Survivin's role in apoptosis, cell division, and cancer.
- Discussion of molecular and immunotherapeutic approaches.
Main Results:
- Survivin expression is upregulated in various human cancers, correlating with poor prognosis.
- It contributes to tumor aggressiveness, apoptosis inhibition, and chemotherapy resistance.
- Survivin is also expressed in stem cells, suggesting a role in their maintenance.
Conclusions:
- Survivin is a key regulator of cellular homeostasis with significant implications in cancer and stem cell biology.
- Targeting Survivin presents a promising avenue for developing cancer vaccines and therapeutics.
- Further research into Survivin's role in stem cell generation and maintenance is warranted.
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