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Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
(Thio)urea-mediated synthesis of functionalized six-membered rings with multiple chiral centers
Giorgos Koutoulogenis1, Nikolaos Kaplaneris1, Christoforos G Kokotos1
1Department of Chemistry, National and Kapodestrian University of Athens, Panepistimiopolis 15771, Athens, Greece.
Abstract:
Organocatalysis, now running its second decade of life, is being considered one of the main tools a synthetic chemist has to perform asymmetric catalysis. In this review the synthesis of six-membered rings, that contain multiple chiral centers, either by a ring closing process or by a functionalization reaction on an already existing six-membered ring, utilizing bifunctional (thio)ureas will be summarized. Initially, the use of primary amine-thioureas as organocatalysts for the above transformation is being discussed, followed by the examples employing secondary amine-thioureas. Finally, the use of tertiary amine-thioureas and miscellaneous examples are presented.
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