Recent advances in C(sp(3))-H bond functionalization via metal-carbene insertions
1Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
Abstract:
The recent development of intermolecular C-H insertion in the application of C(sp(3))-H bond functionalizations, especially for light alkanes, is reviewed. The challenging problem of regioselectivity in C-H bond insertions has been tackled by the use of sterically bulky metal catalysts, such as metal porphyrins and silver(I) complexes. In some cases, high regioselectivity and enantioselectivity have been achieved in the C-H bond insertion of small alkanes. This review highlights the most recent accomplishments in this field.
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