A cross-metathesis approach to novel pantothenamide derivatives
Jinming Guan1, Matthew Hachey1, Lekha Puri1
1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, H3A 0B8, Canada.
Abstract:
Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety. This route however fails in the addition of large substituents. Here we report a new synthetic route that exploits the known allyl derivative, allowing for the installation of larger groups via cross-metathesis. The method was applied in the synthesis of a new pantothenamide with improved stability in human blood.
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